Welcome to the fifth edition of the Compliance, Ethics and Sustainability Journal. The role of Artificial Intelligence in compliance is complicated. Not only has it become an indispensable tool for risk management and data analysis, but AI systems are also the focus of compliance rules and regulations themselves, to ensure that they are being used appropriately without contravening a multitude of domestic and international laws. From automating electronic data reviews to monitoring gifts, hospitality, and travel expenses, and from onboarding decision-making tools to generating creative content, AI is pushing the boundaries of what’s possible in compliance. Yet, as generative AI unlocks ever more complex use cases, compliance professionals face new challenges: educating users, bridging technical gaps, and ensuring responsible adoption. In this edition, we dive into the opportunities and risks of AI in compliance, explore practical strategies for navigating evolving regulations like the EU AI Act, and spotlight how legal and compliance professionals can shape the future of trustworthy AI.